弓形虫和贝氏等孢球虫感染小鼠对麻风分枝杆菌的抗性。
Resistance to Mycobacterium leprae in Mice Infected with Toxoplasma gondii and Besnoitia jellisoni.
机构信息
Division of Allergy, Immunology and Infectious Diseases, Palo Alto Medical Research Foundation, Palo Alto, California 94301.
出版信息
Infect Immun. 1974 Nov;10(5):1068-71. doi: 10.1128/iai.10.5.1068-1071.1974.
Abstract
Mice chronically infected with the intracellular protozoan Toxoplasma gondii or Besnoitia jellisoni were resistant to footpad challenge with Mycobacterium leprae. Resistance was manifested by lower numbers of recoverable M. leprae in the footpads of protozoal-infected mice and was enhanced in Toxoplasma-infected mice by a booster injection of Toxoplasma antigen in the infected footpad. The results suggest a major role for the activated macrophage in the control of M. leprae infection.
摘要
慢性感染细胞内原生动物刚地弓形虫或贝氏等孢球虫的小鼠对麻风分枝杆菌足底挑战具有抗性。这种抗性表现为在原生动物感染的小鼠的足底中可恢复的麻风分枝杆菌数量较少，并且在感染足底中用弓形虫抗原进行增强注射可增强刚地弓形虫感染的小鼠的抗性。结果表明，激活的巨噬细胞在控制麻风分枝杆菌感染中起主要作用。
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