Kasper C S, McMurry K
Department of Dermatology, University of Texas Southwestern Medical School, Dallas 75235-9072.
J Am Acad Dermatol. 1991 Sep;25(3):534-41. doi: 10.1016/0190-9622(91)70236-u.
The case of a 57-year-old diabetic man with necrolytic migratory erythema in the absence of glucagonoma is reported. The clinical and pathologic features of his dermatitis and subsequent clinical course are compared with those of canine superficial necrolytic dermatitis, an unusual cutaneous necrotizing eruption of dogs that is identical histologically to necrolytic migratory erythema. In addition to a necrolytic dermatitis, both our patient and most dogs with superficial necrolytic dermatitis have diabetes mellitus and hepatic failure in the absence of glucagonoma. Thus hyperglucagonemia most likely is not a factor in the origin of the necrotizing dermatitis in this patient or in dogs. The role of hepatocellular dysfunction in the pathogenesis of necrolytic migratory erythema and superficial necrolytic dermatitis is considered.
报告了一例57岁糖尿病男性在无胰高血糖素瘤情况下出现坏死性游走性红斑的病例。将其皮炎的临床和病理特征及后续临床病程与犬浅表坏死性皮炎进行了比较，犬浅表坏死性皮炎是一种不常见的犬皮肤坏死性皮疹，在组织学上与坏死性游走性红斑相同。除坏死性皮炎外，我们的患者和大多数患有浅表坏死性皮炎的犬在无胰高血糖素瘤的情况下都有糖尿病和肝功能衰竭。因此，高胰高血糖素血症很可能不是该患者或犬坏死性皮炎发病的因素。文中考虑了肝细胞功能障碍在坏死性游走性红斑和浅表坏死性皮炎发病机制中的作用。
