Gross T L, O'Brien T D, Davies A P, Long R E
California Dermatopathology Service, West Sacrameto, CA.
J Am Vet Med Assoc. 1990 Dec 15;197(12):1619-22.
A newly recognized disease in dogs, ulcerative dermatosis associated with diabetes mellitus (diabetic dermatopathy), was diagnosed in 2 dogs with pancreatic endocrine tumors that had immunohistologic evidence of glucagon production. Dogs developed diabetes mellitus in the later stages of the illness, months after the skin disease was first observed. Liver disease was identified and characterized by high serum alkaline phosphatase and alanine transaminase activities. Clinically, erythema and crusting involved the footpads, the face, perioral and genital skin, and ventrum. Histologically, skin lesions were intercellular and intracellular edema and necrosis of the upper half of the epidermis and diffuse parakeratosis. Clinically and histologically, skin lesions closely resembled necrolytic migratory erythema of people, a skin disease that usually is associated with a glucagon-secreting pancreatic endocrine tumor and diabetes mellitus (glucagonoma syndrome): The morphologically descriptive term, superficial necrolytic dermatitis, was preferred over the previously proposed names hepatocutaneous syndrome and diabetic dermatopathy, which each connote only a single feature of the disease.
一种新发现的犬类疾病——与糖尿病相关的溃疡性皮肤病（糖尿病性皮肤病），在2只患有胰腺内分泌肿瘤且有胰高血糖素产生免疫组织学证据的犬中被诊断出来。这些犬在疾病后期，即首次观察到皮肤疾病数月后，患上了糖尿病。肝脏疾病通过高血清碱性磷酸酶和丙氨酸转氨酶活性得以识别和表征。临床上，红斑和结痂累及脚垫、面部、口周和生殖器皮肤以及腹部。组织学上，皮肤病变为表皮上半部分的细胞间和细胞内水肿及坏死以及弥漫性角化不全。在临床和组织学上，皮肤病变与人类的坏死松解性游走性红斑极为相似，后者是一种通常与分泌胰高血糖素的胰腺内分泌肿瘤及糖尿病（胰高血糖素瘤综合征）相关的皮肤疾病：形态学描述性术语“浅表坏死松解性皮炎”比先前提出的“肝皮肤综合征”和“糖尿病性皮肤病”更合适，因为后两者仅分别暗示了该疾病的一个单一特征。
