氟康唑、伊曲康唑和酮康唑的体外活性：一项对比研究

Fluconazole, itraconazole and ketoconazole in-vitro activity. A comparative study.

作者信息

Arzeni D, Barchiesi F, Ancarani F, Scalise G

机构信息

Clinica delle Malattie Infettive, Università degli Studi di Ancona, Ospedale Umberto I., Italy.

出版信息

J Chemother. 1991 Jun;3(3):139-42. doi: 10.1080/1120009x.1991.11739080.

DOI:10.1080/1120009x.1991.11739080

PMID:1655990

Abstract

We compared in-vitro activity of fluconazole, itraconazole and ketoconazole by evaluating their Minimal Inhibitory Concentrations (MICs) for 100 fungal strains isolated from different biological specimens of ARC/AIDS patients. A semisolid agar medium was used: this method is suitable for testing molds and yeasts, and can be applied to all azole antifungal drugs. Fluconazole had higher MICs than two other tested drugs, especially for Candida krusei strains; however it never had a MIC higher than 40 mg/l. Itraconazole and ketoconazole had MICs higher than 40mg/l for one Cryptococcus neoformans strain. There were no significant differences for itraconazole and ketoconazole among the tested strains.

摘要

我们通过评估氟康唑、伊曲康唑和酮康唑对从艾滋病患者不同生物标本中分离出的100株真菌的最低抑菌浓度（MIC），比较了它们的体外活性。使用了半固体琼脂培养基：该方法适用于测试霉菌和酵母菌，并且可应用于所有唑类抗真菌药物。氟康唑的MIC高于其他两种受试药物，尤其是对于克柔念珠菌菌株；然而，其MIC从未高于40mg/l。对于一株新型隐球菌，伊曲康唑和酮康唑的MIC高于40mg/l。在受试菌株中，伊曲康唑和酮康唑之间没有显著差异。