Kwekkeboom D J, Krenning E P, Bakker W H, Oei H Y, Splinter T A, Kho G S, Lamberts S W
Department of Nuclear Medicine, University Hospital Dijkzigt, Rotterdam, The Netherlands.
J Nucl Med. 1991 Oct;32(10):1845-8.
Somatostatin receptors have been characterized on biopsy specimens from small-cell lung carcinoma (SCLC) and on cultured human SCLC cells. We recently described the in vivo visualization of various somatostatin receptor-positive tumors, such as carcinoids and endocrine pancreatic tumors, after injection of 123I-Tyr-3-octreotide, a radiolabeled somatostatin analog. In the present study, this imaging procedure using 123I-Tyr-3-octreotide is reported in 11 patients with lung tumors. In five of eight patients with SCLC (63%), we were able to demonstrate tumor deposits using 123I-Tyr-3-octreotide scintigraphy. Unexpected metastases were found in two patients. In one of three patients with SCLC in whom tumor was not visualized, nonvisualization may have been caused by tumor necrosis and recent radiotherapy. In one of two patients with malignant small-cell tumors as described by Askin, the neoplasm was visualized. Like SCLC, these tumors are thought to derive from neuroendocrine cells. In one patient, a squamous-cell carcinoma and a bronchial adenoma were not visualized. We conclude that in the majority of patients with SCLC, the tumor and its metastases can be visualized using 123I-Tyr-3-octreotide scintigraphy. However, the value of this new technique in terms of specificity and sensitivity requires further studies in a larger group of patients.
生长抑素受体已在小细胞肺癌（SCLC）的活检标本以及培养的人SCLC细胞中得到鉴定。我们最近描述了注射放射性标记的生长抑素类似物123I-酪氨酸-3-奥曲肽后，各种生长抑素受体阳性肿瘤，如类癌和内分泌胰腺肿瘤的体内显像。在本研究中，报告了11例肺部肿瘤患者使用123I-酪氨酸-3-奥曲肽的这种成像程序。在8例SCLC患者中的5例（63%），我们能够通过123I-酪氨酸-3-奥曲肽闪烁扫描术显示肿瘤沉积。在2例患者中发现了意外转移灶。在3例SCLC患者中，有1例肿瘤未显影，未显影可能是由肿瘤坏死和近期放疗所致。在2例Askin所描述的恶性小细胞肿瘤患者中，有1例肿瘤显影。与SCLC一样，这些肿瘤被认为起源于神经内分泌细胞。在1例患者中，鳞状细胞癌和支气管腺瘤未显影。我们得出结论，在大多数SCLC患者中，使用123I-酪氨酸-3-奥曲肽闪烁扫描术可显示肿瘤及其转移灶。然而，这项新技术在特异性和敏感性方面的价值需要在更大规模的患者群体中进一步研究。
