粗糙脉孢菌中的氨基酸相互作用
AMINO ACID INTERACTIONS IN NEUROSPORA CRASSA.
作者信息
Soboren J, Nyc J F
机构信息
Department of Physiological Chemistry, University of California, Los Angeles 24, California.
出版信息
J Bacteriol. 1961 Jul;82(1):20-5. doi: 10.1128/jb.82.1.20-25.1961.
Soboren, Josephine (University of California, Los Angeles), and Joseph F. Nyc. Amino acid interactions in Neurospora crassa. J. Bacteriol. 82:20-25. 1961.-A systematic study of the effects of the naturally occurring amino acids on the growth of a wild-type strain of Neurospora crassa focused attention upon l-tryptophan, which exhibits a strong growth inhibitory effect. Further investigation disclosed that other tryptophan metabolites, anthranilic acid, indole, kynurenine, and 3-hydroxykynurenine also inhibit growth. The proposed antimetabolic role of these aromatic compounds explains the poor growth response of certain tryptophan-requiring strains of N. crassa to tryptophan supplements. The growth of normal and mutant strains of N. crassa on media supplemented with tryptophan is influenced by the presence of other amino acids.
索博伦，约瑟芬（加利福尼亚大学洛杉矶分校），以及约瑟夫·F·尼西。粗糙脉孢菌中的氨基酸相互作用。《细菌学杂志》82:20 - 25。1961年。——对天然存在的氨基酸对粗糙脉孢菌野生型菌株生长影响的系统研究将注意力集中在L - 色氨酸上，它表现出强烈的生长抑制作用。进一步研究发现，其他色氨酸代谢产物，邻氨基苯甲酸、吲哚、犬尿氨酸和3 - 羟基犬尿氨酸也抑制生长。这些芳香族化合物所提出的抗代谢作用解释了某些需要色氨酸的粗糙脉孢菌菌株对色氨酸补充剂生长反应不佳的原因。在添加色氨酸的培养基上，粗糙脉孢菌正常菌株和突变菌株的生长受到其他氨基酸存在的影响。
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