吲哚甘油磷酸对粗糙脉孢菌中色氨酸介导的调控的改变。
Alteration of tryptophan-mediated regulation in Neurospora crassa by indoleglycerol phosphate.
作者信息
Turner J R, Matchett W H
出版信息
J Bacteriol. 1968 May;95(5):1608-14. doi: 10.1128/jb.95.5.1608-1614.1968.
Abstract
The accumulation of imidazoleglycerol phosphate during growth of Neurospora crassa in the presence of 3-amino-1,2,4-triazole was found to cause derepression of tryptophan synthetase and to inhibit the induction of kynureninase. Accumulation of indoleglycerol phosphate in response to growth in the presence of indole acrylic acid or anthranilic acid was also accompanied by derepressed synthesis of tryptophan synthetase. Enzyme synthesis in mutants (his-7 and trp-4) unable to form these intermediates was not altered under similar conditions. The rate of formation of tryptophan synthetase and kynureninase was found to differ in the presence of tryptophan and indole.
摘要
发现在3-氨基-1,2,4-三唑存在的情况下，粗糙脉孢菌生长过程中咪唑甘油磷酸的积累会导致色氨酸合成酶的去阻遏，并抑制犬尿氨酸酶的诱导。在吲哚丙烯酸或邻氨基苯甲酸存在的情况下生长时，吲哚甘油磷酸的积累也伴随着色氨酸合成酶的去阻遏合成。在类似条件下，无法形成这些中间产物的突变体（his-7和trp-4）中的酶合成没有改变。发现在色氨酸和吲哚存在的情况下，色氨酸合成酶和犬尿氨酸酶的形成速率不同。
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