Colón J I, Idoine J B, Brand O M, Costlow R D
U.S. Army Biological Laboratories, Fort Detrick, Frederick, Maryland.
J Bacteriol. 1965 Jul;90(1):172-9. doi: 10.1128/jb.90.1.172-179.1965.
Colón, Julio I. (Fort Detrick, Frederick, Md.), Jane B. Idoine, Orville M. Brand, and Richard D. Costlow. Mode of action of an inhibitor from agar on growth and hemagglutination of group A arboviruses. J. Bacteriol. 90:172-179. 1965.-A polysaccharide obtained from agar, and having properties similar to a previously described sulfated polysaccharide, was observed to inhibit growth and hemagglutination of some group A arboviruses. The evidence presented confirms that the inhibitory activity, in part, is the result of direct interaction between the agar polysaccharide (AP) and free virus particles. Additional evidence indicates that inhibition of viral growth also occurs as the result of interaction between AP and the chick-fibroblast cells used for propagation of the virus. The possibility was considered, therefore, that at least two different inhibitors could be present in AP-one that reacts directly with the virus particle and another that reacts with host cells. AP does not induce the production of interferon in the test system used.
科隆，胡利奥·I.（马里兰州弗雷德里克市德特里克堡）、简·B.伊多因、奥维尔·M.布兰德和理查德·D.科斯洛。琼脂中一种抑制剂对A组虫媒病毒生长和血凝作用的作用方式。《细菌学杂志》90:172 - 179。1965年。——从琼脂中获得的一种多糖，其性质与先前描述的硫酸化多糖相似，被观察到可抑制某些A组虫媒病毒的生长和血凝作用。所提供的证据证实，这种抑制活性部分是琼脂多糖（AP）与游离病毒颗粒直接相互作用的结果。另外的证据表明，病毒生长受到抑制也是AP与用于病毒增殖的鸡成纤维细胞相互作用的结果。因此，人们认为AP中可能至少存在两种不同的抑制剂——一种直接与病毒颗粒反应，另一种与宿主细胞反应。在所用的测试系统中，AP不会诱导干扰素的产生。
