Li Li, Zhang Yun, Chen Yu-guo, Li Gui-shuang, Wang Ying, Ma Xiao, Li Ji-fu, Zhong Ming, Zhang Wei
Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Public Health, Department of Cardiology, Qilu Hospital of Shandong University, Jinan 250012, China.
Zhonghua Xin Xue Guan Bing Za Zhi. 2005 Dec;33(12):1106-8.
To investigate the changes of neutrophil myeloperoxidase (MPO) blood concentration gradient between the systemic circulation and the coronary circulation among patients with acute coronary syndrome and its clinical value.
Fifty patients underwent coronary angiography, which including 10 patients in AMI group, 20 patients in UA group, 10 patients in SA group and 10 subjects served as control. The levels of MPO and hs-CRP were measured in the serum of blood collected from femoral vein, aortic artery root and coronary sinus.
Compared with the control, concentrations of LDL in the AMI, UA and SA groups were significantly increased, while the latter three groups did not differ from each other. In the UA patients, the in-gate percentage of MPO decreased in the coronary sinus compared with that in the root of aortic artery (P < 0.01); the in-gate percentage of MPO decreased through coronary circulation more than through systemic circulation (P < 0.001); the average fluorescent intensity of MPO and the concentrations of hs-CRP showed no difference between samples from the coronary sinus and that from the root of aortic artery. In the AMI patients, the average fluorescent intensity of MPO in the coronary sinus was weakened compared with that in the root of aortic artery (P < 0.05); it decreased through coronary circulation more than through systemic circulation (P < 0.001); neither the in-gate percentage of MPO nor the concentrations of hs-CRP showed significant difference between samples from the coronary sinus and that from the root of aortic artery. In the control and SA groups, samples from the femoral vein, the root of aortic artery, and the coronary sinus did not show differences at the serum level of MPO and hs-CRP. In the UA group, the in-gate percentage of MPO correlated positively with the concentration of hs-CRP (r = 0.78, P < 0.01), and with the level of LDL as well (r = 0.52, P < 0.05); In the AMI group, the average fluorescent intensity of MPO correlated negatively with the concentration of hs-CRP (r = -0.80, P < 0.01), and showed no correlation with the level of LDL (r = 0.22, P > 0.05).
MPO is a better marker for inflammation of the local plaques. It may be one of the mechanisms that MPO induces the transforming from LDL to ox-LDL in plaques vulnerability.
探讨急性冠脉综合征患者体循环与冠脉循环之间中性粒细胞髓过氧化物酶（MPO）血浓度梯度的变化及其临床价值。
50例患者接受冠状动脉造影，其中急性心肌梗死（AMI）组10例，不稳定型心绞痛（UA）组20例，稳定型心绞痛（SA）组10例，10例受试者作为对照。测定从股静脉、主动脉根部和冠状窦采集的血液血清中MPO和超敏C反应蛋白（hs-CRP）的水平。
与对照组相比，AMI组、UA组和SA组的低密度脂蛋白（LDL）浓度显著升高，而后三组之间无差异。在UA患者中，冠状窦中MPO的入闸百分比与主动脉根部相比降低（P<0.01）；MPO通过冠脉循环的入闸百分比下降幅度大于通过体循环（P<0.001）；冠状窦样本与主动脉根部样本之间MPO的平均荧光强度和hs-CRP浓度无差异。在AMI患者中，冠状窦中MPO的平均荧光强度与主动脉根部相比减弱（P<0.05）；其通过冠脉循环的下降幅度大于通过体循环（P<0.001）；冠状窦样本与主动脉根部样本之间MPO的入闸百分比和hs-CRP浓度均无显著差异。在对照组和SA组中，股静脉、主动脉根部和冠状窦的样本在MPO和hs-CRP血清水平上无差异。在UA组中，MPO的入闸百分比与hs-CRP浓度呈正相关（r=0.78，P<0.01），与LDL水平也呈正相关（r=0.52，P<0.05）；在AMI组中，MPO的平均荧光强度与hs-CRP浓度呈负相关（r=-0.80，P<0.01），与LDL水平无相关性（r=0.22，P>0.05）。
MPO是局部斑块炎症的较好标志物。它可能是MPO诱导斑块易损性中LDL向氧化型LDL转化的机制之一。
