Li R, Wing L L, Shen Y, Wyatt R J, Kirch D G, Chuang D M
Neuropsychiatry Branch, NIMH Neuroscience Center, St. Elizabeths, Washington, DC 20032.
Neurosci Lett. 1991 Aug 5;129(1):81-5. doi: 10.1016/0304-3940(91)90725-9.
The long-term effects of haloperidol on phosphoinositide turnover in rat brain slices were investigated. Continuous treatment with haloperidol decanoate (21 mg/kg I.M. biweekly for 6 weeks) significantly attenuated carbachol- and norepinephrine (NE)-induced inositol phosphate accumulation in rat frontal cortex and hippocampus. In the striatum, the haloperidol treatment also significantly decreased carbachol-stimulated inositol phosphate level but did not significantly affect NE-sensitive phosphoinositide turnover. These effects were not observed in rats treated with a single dose of haloperidol (1.5 mg/kg). Basel levels of inositol phosphate in these 3 brain regions did not change following continuous or single haloperidol doses.
研究了氟哌啶醇对大鼠脑片磷酸肌醇代谢的长期影响。癸酸氟哌啶醇连续治疗（每两周肌肉注射21mg/kg，共6周）显著减弱了卡巴胆碱和去甲肾上腺素（NE）诱导的大鼠额叶皮质和海马体中肌醇磷酸的积累。在纹状体中，氟哌啶醇治疗也显著降低了卡巴胆碱刺激的肌醇磷酸水平，但对NE敏感的磷酸肌醇代谢没有显著影响。在单次注射氟哌啶醇（1.5mg/kg）的大鼠中未观察到这些效应。连续或单次给予氟哌啶醇后，这三个脑区的肌醇磷酸基础水平没有变化。
