Claustre Y, Bénavidès J, Scatton B
Laboratoires d'Etudes et de Recherches Synthélabo (L.E.R.S.), Biology Department, Bagneux, France.
Eur J Pharmacol. 1988 Apr 27;149(1-2):149-53. doi: 10.1016/0014-2999(88)90054-4.
The selective 5-HT1A agonists, 8-hydroxy-2-(di-n-dipropylamino)tetralin (8-OH-DPAT) and ipsapirone, and the 5-HT1A/5-HT1B agonist, 1-(m-trifluoromethylphenyl)piperazine, partially inhibited the carbachol-stimulated [3H]inositol phosphate formation in rat hippocampal slices. The effect of 8-OH-DPAT was antagonized by cyanopindolol. Selective 5-HT1B, 5-HT2 and 5-HT3 agonists were inactive. 8-OH-DPAT failed to affect the phosphoinositide turnover stimulated by KCl, quisqualate or noradrenaline in hippocampal slices and by carbachol in striatal or cortical slices. These results suggest that 5-HT1A receptors are negatively coupled to phosphoinositide phosphodiesterase in the hippocampus.
选择性5-羟色胺1A受体激动剂8-羟基-2-（二正丙基氨基）四氢萘（8-OH-DPAT）和ipsapirone，以及5-羟色胺1A/5-羟色胺1B受体激动剂1-（间三氟甲基苯基）哌嗪，部分抑制了卡巴胆碱刺激的大鼠海马切片中[3H]肌醇磷酸的形成。8-OH-DPAT的作用被氰吲哚洛尔拮抗。选择性5-羟色胺1B、5-羟色胺2和5-羟色胺3受体激动剂无活性。8-OH-DPAT未能影响海马切片中由氯化钾、quisqualate或去甲肾上腺素以及纹状体或皮质切片中由卡巴胆碱刺激的磷酸肌醇转换。这些结果表明，5-羟色胺1A受体与海马体中的磷酸肌醇磷酸二酯酶呈负性偶联。
