萘醌衍生物的合成及其抗真菌活性评价
Synthesis and evaluation of antifungal activity of naphthoquinone derivatives.
作者信息
Errante Giaccomo, La Motta Grazia, Lagana Catarina, Wittebolle Vierle, Sarciron Marie-Elisabeth, Barret Roland
机构信息
Laboratoire de chimie thérapeutique, université Claude-Bernard, faculté de Pharmacie, 8 avenue Rockefeller, 69373 Lyon cedex 08, France.
出版信息
Eur J Med Chem. 2006 Jun;41(6):773-8. doi: 10.1016/j.ejmech.2006.02.003. Epub 2006 Mar 24.
PMID:16563569
Abstract
3-Arylamino-2-phenylsulfinylnaphthoquinones, 2,3-diarylthio-naphthoquinones and 2-phenylsulfinyl-3-arylthio-1,4-dihydronaphtalenes are synthesized and tested against five fungi. The activities of these products were better than amphotericine B against all the strains except for Candida albicans.
摘要
合成了3-芳氨基-2-苯基亚磺酰基萘醌、2,3-二芳硫基萘醌和2-苯基亚磺酰基-3-芳硫基-1,4-二氢萘，并针对五种真菌进行了测试。除白色念珠菌外，这些产物对所有菌株的活性均优于两性霉素B。
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