Fahmy H T
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Alexandria, Alexandria, Egypt.
Boll Chim Farm. 2001 Nov-Dec;140(6):422-7.
The rise in the incidence of fungal infections over the past two decades, particularly those caused by opportunistic pathogens in immune-compromised patients, has strengthened the need for new antifungal drugs. New triazole derivatives were synthesized and evaluated for their in-vitro antifungal activities against three species of fungi. Most of the prepared compounds showed good antifungal activity. Three compounds exhibited pronounced activity against Cryptococcus neoformans with MIC less than 12.5 g/ml.
在过去二十年中，真菌感染的发病率不断上升，尤其是免疫功能低下患者中由机会性病原体引起的感染，这增强了对新型抗真菌药物的需求。合成了新的三唑衍生物，并评估了它们对三种真菌的体外抗真菌活性。大多数制备的化合物显示出良好的抗真菌活性。三种化合物对新型隐球菌表现出显著活性，其最低抑菌浓度小于12.5微克/毫升。
