白细胞介素-1受体相关激酶-4抑制剂的发现及初步构效关系研究
Discovery and initial SAR of inhibitors of interleukin-1 receptor-associated kinase-4.
作者信息
Powers Jay P, Li Shyun, Jaen Juan C, Liu Jinqian, Walker Nigel P C, Wang Zhulun, Wesche Holger
机构信息
Amgen Inc., 1120 Veterans Boulevard, South San Francisco, CA 94080, USA.
出版信息
Bioorg Med Chem Lett. 2006 Jun 1;16(11):2842-5. doi: 10.1016/j.bmcl.2006.03.020. Epub 2006 Mar 24.
PMID:16563752
Abstract
High-throughput screening of a small-molecule compound library resulted in the identification of a novel series of N-acyl 2-aminobenzimidazoles that are potent inhibitors of interleukin-1 receptor-associated kinase-4.
摘要
对一个小分子化合物文库进行高通量筛选，结果鉴定出一系列新型的N-酰基-2-氨基苯并咪唑，它们是白细胞介素-1受体相关激酶-4的有效抑制剂。
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