• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Design, synthesis, and preliminary biological evaluation of 2,3-dihydro-3-hydroxymethyl-1,4-benzoxazine derivatives.

作者信息

Jiao Pei-Fu, Zhao Bao-Xiang, Wang Wei-Wei, He Qiu-Xia, Wan Mao-Sheng, Shin Dong-Soo, Miao Jun-Ying

机构信息

Institute of Organic Chemistry, School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, China.

出版信息

Bioorg Med Chem Lett. 2006 Jun 1;16(11):2862-7. doi: 10.1016/j.bmcl.2006.03.013. Epub 2006 Mar 24.

DOI:10.1016/j.bmcl.2006.03.013
PMID:16563757
Abstract

We synthesized a series of novel small molecules, 2,3-dihydro-3-hydroxymethyl-1,4-benzoxazine derivatives, by tandem reduction-oxirane opening of 2-nitroaroxymethyloxiranes in moderate or excellent yields. We investigated the effects of all of the compounds on HUVEC apoptosis and A549 cell growth. The results showed that 6,8-dichloro-2,3-dihydro-3-hydroxymethyl-1,4-benzoxazine was the most effective small molecule in promoting HUVEC apoptosis and inhibiting A549 cell proliferation, but 6-amino-2,3-dihydro-3-hydroxymethyl-1,4-benzoxazine could remarkably inhibit HUVEC apoptosis and might induce the formation of microvessel.

摘要

相似文献

1
Design, synthesis, and preliminary biological evaluation of 2,3-dihydro-3-hydroxymethyl-1,4-benzoxazine derivatives.
Bioorg Med Chem Lett. 2006 Jun 1;16(11):2862-7. doi: 10.1016/j.bmcl.2006.03.013. Epub 2006 Mar 24.
2
Protective effects of a benzoxazine derivative against oxidized LDL-induced apoptosis and the increases of integrin beta4, ROS, NF-kappaB and P53 in human umbilical vein endothelial cells.一种苯并恶嗪衍生物对氧化型低密度脂蛋白诱导的人脐静脉内皮细胞凋亡以及整合素β4、活性氧、核因子κB和P53升高的保护作用。
Bioorg Med Chem Lett. 2009 May 15;19(10):2896-900. doi: 10.1016/j.bmcl.2009.03.070. Epub 2009 Mar 21.
3
Novel 2,3-dihydro-1,4-benzoxazines as potent and orally bioavailable inhibitors of tumor-driven angiogenesis.新型2,3-二氢-1,4-苯并恶嗪作为肿瘤驱动血管生成的强效口服生物可利用抑制剂
J Med Chem. 2008 Mar 27;51(6):1695-705. doi: 10.1021/jm701129j. Epub 2008 Feb 27.
4
Novel small molecule inhibitors for prostate-specific antigen.新型前列腺特异性抗原小分子抑制剂
Prostate. 2008 Aug 1;68(11):1143-51. doi: 10.1002/pros.20773.
5
Design, synthesis, and preliminary biological evaluation of novel ethyl 1-(2'-hydroxy-3'-aroxypropyl)-3-aryl-1H-pyrazole-5-carboxylate.新型1-(2'-羟基-3'-芳氧基丙基)-3-芳基-1H-吡唑-5-羧酸乙酯的设计、合成及初步生物学评价
Bioorg Med Chem Lett. 2006 Dec 15;16(24):6342-7. doi: 10.1016/j.bmcl.2006.09.008. Epub 2006 Sep 26.
6
Studies toward the discovery of the next generation of antidepressants. Part 5: 3,4-Dihydro-2H-benzo[1,4]oxazine derivatives with dual 5-HT1A receptor and serotonin transporter affinity.新一代抗抑郁药的发现研究。第5部分：具有5-HT1A受体和5-羟色胺转运体双重亲和力的3,4-二氢-2H-苯并[1,4]恶嗪衍生物
Bioorg Med Chem Lett. 2006 Mar 1;16(5):1338-41. doi: 10.1016/j.bmcl.2005.11.054. Epub 2005 Dec 5.
7
Development of 3,4-dihydro-2H-benzo[1,4]oxazine derivatives as dual thromboxane A2 receptor antagonists and prostacyclin receptor agonists.
Bioorg Med Chem. 2006 Mar 15;14(6):2005-21. doi: 10.1016/j.bmc.2005.10.050. Epub 2005 Nov 16.
8
Highly efficient copper-catalyzed domino ring opening and Goldberg coupling cyclization for the synthesis of 3,4-dihydro-2H-1,4-benzoxazines.用于合成3,4-二氢-2H-1,4-苯并恶嗪的高效铜催化多米诺开环和戈德堡偶联环化反应
Org Lett. 2009 May 7;11(9):1923-6. doi: 10.1021/ol9003299.
9
Synthesis, antimicrobial activity and QSARs of new benzoxazine-3-ones.新型苯并恶嗪-3-酮的合成、抗菌活性及定量构效关系
Eur J Med Chem. 2006 Dec;41(12):1398-404. doi: 10.1016/j.ejmech.2006.06.011. Epub 2006 Sep 22.
10
Novel 2-alkylamino-1,4-benzoxazine derivatives as potent neuroprotective agents: structure-activity relationship studies.
J Med Chem. 2005 Feb 24;48(4):1282-6. doi: 10.1021/jm040874m.

引用本文的文献

1
Synthesis, Formation Mechanisms, and Molecular Dynamics Simulation of Novel Benzothiazole and Benzo[1,4]oxazin-3(4)-one as Potential Acetylcholinesterase Inhibitors.新型苯并噻唑和苯并[1,4]恶嗪-3(4)-酮作为潜在乙酰胆碱酯酶抑制剂的合成、形成机制及分子动力学模拟
ACS Omega. 2025 Mar 10;10(11):10835-10851. doi: 10.1021/acsomega.4c06760. eCollection 2025 Mar 25.
2
Long Noncoding RNA LOC100129973 Suppresses Apoptosis by Targeting miR-4707-5p and miR-4767 in Vascular Endothelial Cells.长链非编码RNA LOC100129973通过靶向血管内皮细胞中的miR-4707-5p和miR-4767抑制细胞凋亡。
Sci Rep. 2016 Feb 18;6:21620. doi: 10.1038/srep21620.
3
Hydrogen Sulfide Ameliorates Early Brain Injury Following Subarachnoid Hemorrhage in Rats.
硫化氢改善大鼠蛛网膜下腔出血后的早期脑损伤。
Mol Neurobiol. 2016 Aug;53(6):3646-3657. doi: 10.1007/s12035-015-9304-1. Epub 2015 Jun 26.
4
Targeting annexin A7 by a small molecule suppressed the activity of phosphatidylcholine-specific phospholipase C in vascular endothelial cells and inhibited atherosclerosis in apolipoprotein E⁻/⁻mice.小分子靶向结合膜联蛋白 A7 抑制血管内皮细胞中磷酯酰胆碱特异性磷脂酶 C 的活性，从而抑制载脂蛋白 E 基因敲除小鼠的动脉粥样硬化形成。
Cell Death Dis. 2013 Sep 19;4(9):e806. doi: 10.1038/cddis.2013.317.