一种苯并恶嗪衍生物对氧化型低密度脂蛋白诱导的人脐静脉内皮细胞凋亡以及整合素β4、活性氧、核因子κB和P53升高的保护作用。
Protective effects of a benzoxazine derivative against oxidized LDL-induced apoptosis and the increases of integrin beta4, ROS, NF-kappaB and P53 in human umbilical vein endothelial cells.
作者信息
Liu Xia, Zhao Jing, Xu JiPing, Zhao BaoXiang, Zhang Yun, Zhang ShangLi, Miao JunYing
机构信息
Institute of Developmental Biology, Shandong University, Jinan, China.
出版信息
Bioorg Med Chem Lett. 2009 May 15;19(10):2896-900. doi: 10.1016/j.bmcl.2009.03.070. Epub 2009 Mar 21.
To investigate whether 6-amino-2,3-dihydro-3-hydroxymethyl-1,4-benzoxazine (ABO) inhibits oxidized low-density lipoprotein (oxLDL)-induced human umbilical vein endothelial cell (HUVEC) apoptosis, we treated HUVECs with oxLDL in the absence or presence of ABO. The results showed that ABO could act as an effective inhibitor of oxLDL-elicited HUVEC apoptosis by inhibiting the levels of integrin beta4, reactive oxygen species (ROS), NF-kappaB and P53, and suppressing NF-kappaB nuclear translocation.
为了研究6-氨基-2,3-二氢-3-羟甲基-1,4-苯并恶嗪（ABO）是否抑制氧化型低密度脂蛋白（oxLDL）诱导的人脐静脉内皮细胞（HUVEC）凋亡，我们在有或没有ABO存在的情况下用oxLDL处理HUVEC。结果表明，ABO可通过抑制整合素β4、活性氧（ROS）、核因子κB（NF-κB）和P53的水平，并抑制NF-κB核转位，作为oxLDL诱导的HUVEC凋亡的有效抑制剂。
Zotero 插件