Immunohistochemical demonstration of papillomavirus infection in condylomatous and preneoplastic lesions of the lower female genital tract.

An immunoperoxidase study of 250 cases of condyloma of the female genital tract showed HPV expression in 45% of the cases. The flat form was the most frequent (191/250 cases). Condylomatous lesions were associated with dysplasia, in situ or micro-invasive carcinoma in 43% of the cases. The results support the role of the HPV as a possible carcinogenic agent in the female genital tract.