Beauchamp J F, Lemieux M, Drapeau G, Rioux F
Centre de Recherche, Hôtel-Dieu de Québec, Canada.
Peptides. 1991 May-Jun;12(3):513-21. doi: 10.1016/0196-9781(91)90094-6.
Single intraperitoneal (IP) injection of bradykinin (BK) in anesthetized guinea pigs caused concentration-related pressor effects and slight, not significant tachycardia. Intravenous injections of BK in the same animal model evoked hypotension and a marked tachycardia. IP injection of des-Arg9-BK, a selective B1 receptor agonist, caused no changes of blood pressure or heart rate. The pressor response to IP BK was reduced by concomitant IP injection of lidocaine or of D-Arg[Hyp3,D-Phe7,Leu8]BK, a B2 receptor antagonist. It was also inhibited by acute animal pretreatment with sympatholytic drugs, by chronic animal exposure to capsaicin, or acute spinalization, but it was not affected by atropine, propranolol, indomethacin, [Leu8]des-Arg9-BK, a B1 receptor antagonist, or by acute cervical vagotomy. These results suggest that pressor responses to IP BK in anesthetized guinea pigs are reflex in nature, involving abdominal, capsaicin-sensitive, nonvagal visceral afferents, efferent components of the sympathetic nervous system and possibly supraspinal centers, and likely to be mediated by B2 receptors of kinins presumably located on abdominal visceral afferents.
在麻醉的豚鼠中，单次腹腔内注射缓激肽（BK）可引起与浓度相关的升压效应和轻微但不显著的心动过速。在同一动物模型中静脉注射BK则诱发低血压和明显的心动过速。腹腔内注射选择性B1受体激动剂去精氨酸9 - 缓激肽（des - Arg9 - BK）不会引起血压或心率变化。腹腔内同时注射利多卡因或B2受体拮抗剂D - 精氨酸[Hyp3，D - 苯丙氨酸7，亮氨酸8]缓激肽（D - Arg[Hyp3，D - Phe7，Leu8]BK）可降低腹腔内注射BK后的升压反应。急性用抗交感神经药物预处理动物、慢性使动物暴露于辣椒素或急性脊髓横断也可抑制该反应，但阿托品、普萘洛尔、吲哚美辛、B1受体拮抗剂[亮氨酸8]去精氨酸9 - 缓激肽（[Leu8]des - Arg9 - BK）或急性颈迷走神经切断术对其无影响。这些结果表明，麻醉豚鼠对腹腔内注射BK的升压反应本质上是反射性的，涉及腹部、对辣椒素敏感的非迷走内脏传入神经、交感神经系统的传出成分以及可能的脊髓上中枢，并且可能由推测位于腹部内脏传入神经上的激肽B2受体介导。
