表观遗传学在特发性男性不育中的作用。
The role of epigenetics in idiopathic male infertility.
作者信息
Gunes Sezgin, Arslan Mehmet Alper, Hekim Gulgez Neslihan Taskurt, Asci Ramazan
机构信息
Faculty of Medicine, Department of Medical Biology, Ondokuz Mayis University, 55139, Samsun, Turkey.
Health Sciences Institute, Department of Multidisciplinary Molecular Medicine, Ondokuz Mayis University, 55139, Samsun, Turkey.
出版信息
J Assist Reprod Genet. 2016 May;33(5):553-569. doi: 10.1007/s10815-016-0682-8. Epub 2016 Mar 3.
Infertility is a complex disorder with multiple genetic and environmental causes. Although some specific mutations have been identified, other factors responsible for sperm defects remain largely unknown. Despite considerable efforts to identify the pathophysiology of the disease, we cannot explain the underlying mechanisms of approximately half of infertility cases. This study reviews current data on epigenetic regulation and idiopathic male infertility. Recent data have shown an association between epigenetic modifications and idiopathic infertility. In this regard, epigenetics has emerged as one of the promising research areas in understanding male infertility. Many studies have indicated that epigenetic modifications, including DNA methylation in imprinted and developmental genes, histone tail modifications and short non-coding RNAs in spermatozoa may have a role in idiopathic male infertility.
不孕不育是一种由多种遗传和环境因素导致的复杂病症。尽管已经鉴定出一些特定的突变，但导致精子缺陷的其他因素在很大程度上仍不为人知。尽管为确定该疾病的病理生理学付出了巨大努力，但我们仍无法解释约一半不孕不育病例的潜在机制。本研究综述了关于表观遗传调控与特发性男性不育的当前数据。最近的数据表明表观遗传修饰与特发性不育之间存在关联。在这方面，表观遗传学已成为理解男性不育的一个有前景的研究领域之一。许多研究表明，表观遗传修饰，包括印记基因和发育基因中的DNA甲基化、精子中的组蛋白尾部修饰以及短链非编码RNA，可能在特发性男性不育中发挥作用。
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