De Pablo F, Robics H L, Caldés T, Alemany J, Scavo L, Serrano J
Section on Receptors and Hormone Action, National Center for Research Resources, National Institutes of Health, Bethesda, Maryland 20892.
Poult Sci. 1991 Aug;70(8):1790-6. doi: 10.3382/ps.0701790.
The avian embryo has been a useful model system for studies on the role of insulin and its close relative insulin-like growth factor-I (IGF-I) in development. The unfertilized chicken egg contains both peptides from maternal origin, and the embryo expresses insulin and IGF-I before the major organs are formed. Insulin receptors and IGF-I receptors are found in the blastoderm and in all tissues examined during organogenesis. When exogenous insulin or IGF-I are added to the embryo, growth and differentiation events are stimulated. By contrast, insulin antibodies and insulin receptor antibodies retard embryo development. In embryos cultured ex ovo, in which growth is impaired, the levels of serum IGF-I are decreased.
禽类胚胎一直是研究胰岛素及其近亲胰岛素样生长因子-I（IGF-I）在发育过程中作用的有用模型系统。未受精的鸡蛋含有来自母体的这两种肽，并且胚胎在主要器官形成之前就表达胰岛素和IGF-I。在胚盘以及器官发生过程中检查的所有组织中都发现了胰岛素受体和IGF-I受体。当向胚胎添加外源性胰岛素或IGF-I时，生长和分化事件会受到刺激。相比之下，胰岛素抗体和胰岛素受体抗体则会阻碍胚胎发育。在体外培养的胚胎中，其生长受到损害，血清IGF-I水平会降低。
