Carro-Juárez M, Rodríguez-Manzo G
Laboratorio de Comportamiento Reproductivo, Escuela de Medicina Veterinaria y Zootecnia, Universidad Autónoma de Tlaxcala, C.P.90000, Tlaxcala, México.
Brain Res. 2006 Apr 21;1084(1):54-60. doi: 10.1016/j.brainres.2006.02.038. Epub 2006 Mar 27.
Substantial progress has been made during recent years in elucidating the control of male ejaculatory function by the central nervous system. These efforts have revealed the participation of a central pattern generator in the control of ejaculation. There is a strong similarity in the neural organization of male and female sexual functions. In the present study, the hypothesis that the spinal generator for ejaculation was present and functional in the female rat was evaluated. To this purpose, the expression of the ejaculatory motor pattern and its pharmacological activation in spinally transected female rats were investigated. Results revealed the presence in females of the already described rhythmic ejaculatory motor pattern of male rats. This ejaculatory motor pattern could be registered in the urethralis muscle of the female rat after mechanical stimulation of the urethra, vagina and clitoris and consisted, as in the male rat, of a first ejaculatory motor train followed by an after-discharge component. Besides, the female genital ejaculatory motor pattern could be pharmacologically induced by the systemic injection of sodium nitroprusside with similar motor characteristics. No significant differences between the sensorial and pharmacologically induced female genital motor patterns were found. Present findings provide evidence for the presence of the genital motor pattern of ejaculation in female rats and suggest that the spinal generator for ejaculation is also present and functional in this gender.
近年来，在阐明中枢神经系统对男性射精功能的控制方面取得了重大进展。这些研究揭示了中枢模式发生器在射精控制中的作用。男性和女性性功能的神经组织有很强的相似性。在本研究中，评估了雌性大鼠中存在并发挥作用的射精脊髓发生器这一假说。为此，研究了脊髓横断雌性大鼠射精运动模式的表达及其药理学激活。结果显示雌性大鼠存在已描述的雄性大鼠有节奏的射精运动模式。在对雌性大鼠的尿道、阴道和阴蒂进行机械刺激后，可在其尿道肌中记录到这种射精运动模式，与雄性大鼠一样，它由第一个射精运动序列和随后的放电后成分组成。此外，通过全身注射硝普钠可药理学诱导出具有相似运动特征的雌性生殖器射精运动模式。在感觉诱导和药理学诱导的雌性生殖器运动模式之间未发现显著差异。目前的研究结果为雌性大鼠存在射精的生殖器运动模式提供了证据，并表明射精脊髓发生器在该性别中也存在并发挥作用。
