Wren Stephen A C, Tchelitcheff Pierre
Analytical Development, PAR&D, AstraZeneca, Silk Business Park, Macclesfield, Cheshire, UK.
J Chromatogr A. 2006 Jun 30;1119(1-2):140-6. doi: 10.1016/j.chroma.2006.02.052. Epub 2006 Mar 27.
Ultra-performance liquid chromatography (UPLC) has been investigated as an alternative to HPLC for the analysis of pharmaceutical development compounds. We present data on three compounds showing that significant reductions in separation time can be achieved without compromising the separation quality. Results from precision and comparative studies indicate that UPLC is a suitable technique for routine pharmaceutical analysis.
超高效液相色谱法（UPLC）已被研究作为高效液相色谱法（HPLC）的替代方法用于药物研发化合物的分析。我们给出了三种化合物的数据，表明在不影响分离质量的情况下可以显著缩短分离时间。精密度和对比研究的结果表明UPLC是一种适用于常规药物分析的技术。
