Maeda H, Akaike T
Department of Microbiology, Kumamoto University Medical School, Japan.
Proc Soc Exp Biol Med. 1991 Nov;198(2):721-7. doi: 10.3181/00379727-198-43309c.
Oxygen free radicals such as superoxide anion (O2-) were generated markedly in influenza virus-infected mouse lung, and these molecular species were identified as the potent pathogenic agents. This finding has many important implications for understanding viral pathogenesis: namely, the direct viral cytotoxicity (referred cytopathic effect) is only a fraction of several types of events induced by virus infection. The toxicity and reactivity of oxygen radicals, which are presumably generated in excessive amounts by the overreaction of the host's immune response against the organs or tissues in which viruses are replicating, may explain the mechanism of tissue injuries observed not only in influenza virus infection in mice, but also in other types of viral diseases in which immunological interactions are usually involved.
在流感病毒感染的小鼠肺中，超氧阴离子（O2-）等氧自由基大量产生，这些分子被确定为强效病原体。这一发现对于理解病毒发病机制具有许多重要意义：也就是说，病毒直接的细胞毒性（即细胞病变效应）只是病毒感染引发的几种事件中的一部分。氧自由基的毒性和反应性可能是宿主针对病毒复制所在器官或组织的免疫反应过度而大量产生的，这或许可以解释不仅在小鼠流感病毒感染中，而且在通常涉及免疫相互作用的其他类型病毒疾病中所观察到的组织损伤机制。
