Mandenoff A, Seyrig J A, Betoulle D, Brigant L, Melchior J C, Apfelbaum M
Laboratoire de Nutrition Humaine, INSERM U 286, Faculté X. Bichat, Paris, France.
Pharmacol Biochem Behav. 1991 May;39(1):215-7. doi: 10.1016/0091-3057(91)90425-2.
The effect of U50,488H (a selective kappa opiate agonist) on oxygen consumption was measured in either resting and free-moving rats. In both states, U50,488H provokes an increase in oxygen consumption. In resting rats, the increase occurs at lower doses than in free-moving rats. The explanation could be that in the free-moving rats the drug results in an increase in energy expenditure, partially compensated by a decrease in activity.
在静息和自由活动的大鼠中测量了U50,488H（一种选择性κ阿片受体激动剂）对氧消耗的影响。在这两种状态下，U50,488H都会引起氧消耗增加。在静息大鼠中，较低剂量时就会出现这种增加，而在自由活动的大鼠中则需要更高剂量。其原因可能是在自由活动的大鼠中，该药物导致能量消耗增加，部分通过活动减少得到补偿。
