Kley H K, Nieschlag E, Krüskemper H L
Acta Endocrinol (Copenh). 1975 May;79(1):95-101. doi: 10.1530/acta.0.0790095.
Twelve men, 19-40 years old, and 12 men, 60-86 years old, were given ACTH and in a second test series, HCG. Oestrone, oestradiol-17beta and cortisol were measured in the plasma before and after stimulation. Under basal conditions oestrone and oestradiol as well as the percentage binding of testosterone increased significantly with age, whereas cortisol remained unchanged. The administration of HCG resulted in higher levels of both plasma oestrone and oestradiol in older subjects than in younger ones, although the percentage increase was smaller. ACTH stimulation leads to higher levels of oestrone in the older group, whereas oestradiol remained unchanged. Cortisol rose 3.5 fold in both groups. Regarding absolute concentrations of oestrone and oestradiol the ability of the adrenals and of the testes to respond to exogenous gonadotrophin and adrenocorticotrophin appeared to be preserved despite ageing, though the relative responses of oestrone and oestradiol after HCG and of oestrone after ACTH were decreased in old as compared to young men.
12名年龄在19至40岁之间的男性以及12名年龄在60至86岁之间的男性接受了促肾上腺皮质激素（ACTH）治疗，在第二个测试系列中，他们接受了人绒毛膜促性腺激素（HCG）治疗。在刺激前后测量血浆中的雌酮、雌二醇-17β和皮质醇。在基础条件下，雌酮、雌二醇以及睾酮的结合百分比随年龄显著增加，而皮质醇保持不变。给予HCG后，老年受试者血浆中雌酮和雌二醇的水平高于年轻受试者，尽管增加的百分比较小。ACTH刺激导致老年组雌酮水平升高，而雌二醇保持不变。两组皮质醇均升高了3.5倍。关于雌酮和雌二醇的绝对浓度，尽管衰老，但肾上腺和睾丸对外源性促性腺激素和促肾上腺皮质激素的反应能力似乎得以保留，不过与年轻男性相比，老年男性在接受HCG后雌酮和雌二醇的相对反应以及接受ACTH后雌酮的相对反应均降低。
