服用硫酸雌酮和雌二醇的绝经后女性血清雌激素浓度的比较。
Comparison of serum oestrogen concentrations in post-menopausal women taking oestrone sulphate and oestradiol.
作者信息
Anderson A B, Sklovsky E, Sayers L, Steele P A, Turnbull A C
出版信息
Br Med J. 1978 Jan 21;1(6106):140-2. doi: 10.1136/bmj.1.6106.140.
Abstract
Mean serum concentrations of oestradiol-17beta, oestrone, and oestrone sulphate in postmenopausal women were the same when measured up to six hours after treatment with either piperazine oestrone sulphate 1.5 mg or oestradiol valerate 2 mg. Maximum concentrations of oestradiol were less than those of oestrone, but oestrone sulphate reached concentrations about 30 times higher than those of oestrone. The rapid conversion of oestradiol valerate to oestrone and oestrone sulphate does not support the suggestion that in menopausal women oestradiol is less likely to be associated with a risk of endometrial carcinoma than oestrone sulphate, since the two preparations appear to become identical after ingestion.
摘要
绝经后女性在接受1.5毫克硫酸哌嗪雌酮或2毫克戊酸雌二醇治疗后长达6小时进行测量时，其血清中17β-雌二醇、雌酮和硫酸雌酮的平均浓度相同。雌二醇的最高浓度低于雌酮，但硫酸雌酮的浓度比雌酮高出约30倍。戊酸雌二醇迅速转化为雌酮和硫酸雌酮，这并不支持以下观点：在绝经后女性中，与硫酸雌酮相比，雌二醇与子宫内膜癌风险相关的可能性较小，因为这两种制剂在摄入后似乎变得相同。
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