Schmitt Claus Peter, Odenwald Tobias, Ritz Eberhard
Department of Pediatrics, Ruperto Carola University, Heidelberg, Germany.
J Am Soc Nephrol. 2006 Apr;17(4 Suppl 2):S78-80. doi: 10.1681/ASN.2005121338.
Calcemia is a risk factor for cardiovascular (CV) events in dialyzed patients. The relation between serum calcium and cardiovascular events is continuous and linear. Calcium plays a potent role in the genesis of cardiovascular dysfunction, particularly by promoting vascular calcification. Parathyroid hormone (PTH) also is associated with increased CV risk in both primary and secondary hyperparathyroidism. There is a nonlinear relationship between PTH and CV risk; both high and low PTH concentrations increase CV risk. The CV risk profile (BP, dyslipidemia) is strikingly ameliorated by the administration of calcimimetics. Apart from lowering PTH, whether calcimimetics have intrinsic effects on CV risk profile is unknown.
血钙过高是透析患者发生心血管（CV）事件的一个危险因素。血清钙与心血管事件之间的关系是连续且呈线性的。钙在心血管功能障碍的发生过程中起着重要作用，特别是通过促进血管钙化。甲状旁腺激素（PTH）在原发性和继发性甲状旁腺功能亢进中也与心血管风险增加有关。PTH与心血管风险之间存在非线性关系；PTH浓度过高和过低都会增加心血管风险。使用拟钙剂可显著改善心血管风险状况（血压、血脂异常）。除了降低PTH外，拟钙剂对心血管风险状况是否有内在影响尚不清楚。
