Capewell S, Sankaran R, Lamb D, McIntyre M, Sudlow M F
Department of Medicine, Royal Infirmary, Edinburgh.
Thorax. 1991 Aug;46(8):565-8. doi: 10.1136/thx.46.8.565.
The Edinburgh Lung Cancer Group registered 3070 new patients with lung cancer in the five years 1981-5 from a catchment population of 950,000. After review only 74 (2%) were classified as lifelong non-smokers. They differed significantly from the 2996 smokers with lung cancer in that far more were female (77% v 26%) and their mean age was higher (75.4 v 68.0 years). More were in the worst Karnofsky performance categories and fewer patients underwent surgery. The stages of disease were similarly distributed in the two groups and the five year survival was equally poor (5%). Histological cell type was determined in 59 of the 74 patients. All histological cell types were present. More non-smokers had adenocarcinoma than smokers (42% v 13%) and fewer had squamous cell carcinoma (32% v 49%) or small cell carcinoma (15% v 24%). Lung cancer in lifelong non-smokers is uncommon and the diagnosis should therefore always be questioned.
爱丁堡肺癌研究小组在1981年至1985年的五年间，从95万的目标人群中登记了3070例肺癌新患者。经过复查，只有74例（2%）被归类为终生不吸烟者。他们与2996例吸烟肺癌患者有显著差异，其中女性比例更高（77%对26%），平均年龄也更大（75.4岁对68.0岁）。更多患者处于卡诺夫斯基表现最差的类别，接受手术的患者较少。两组疾病分期分布相似，五年生存率同样较差（5%）。74例患者中的59例确定了组织学细胞类型。所有组织学细胞类型均有出现。不吸烟者患腺癌的比例高于吸烟者（42%对13%），患鳞状细胞癌（32%对49%）或小细胞癌（15%对24%）的比例低于吸烟者。终生不吸烟者患肺癌的情况并不常见，因此对此诊断应始终持怀疑态度。
