Ashley D J, Davies H D
Thorax. 1969 Jul;24(4):446-50. doi: 10.1136/thx.24.4.446.
Eighty-three instances of lung cancer in women are presented. The frequency of the condition is lower in women than in men but the tumours in women tend to be less well differentiated and are less likely to be resectable than in men. The frequency of extrathoracic metastases at the time of diagnosis is greater in women than in men. It is suggested that the immunological defences of women are better than those of men because of sex-linked genes, present in double dose in the female, which are concerned with the immunological mechanisms, and that the clinically apparent tumours are those which, by virtue of their greater intrinsic malignancy, can overcome the defence mechanisms.
本文报告了83例女性肺癌病例。该疾病在女性中的发病率低于男性，但女性的肿瘤往往分化程度较低，与男性相比，可切除性较低。女性在诊断时胸外转移的发生率高于男性。有人认为，由于与免疫机制有关的性连锁基因在女性中呈双倍剂量存在，女性的免疫防御能力优于男性，而临床上明显的肿瘤是那些因其内在恶性程度较高而能够克服防御机制的肿瘤。
