Weissenberg S, Ovadia M, Fleminger G, Kochva E
Department of Zoology, George S. Wise Faculty of Life Sciences, Tel-Aviv University, Israel.
Toxicon. 1991;29(7):807-18. doi: 10.1016/0041-0101(91)90217-f.
Several antihemorrhagic factors isolated from C. atrox serum are glycoproteins with mol. wt ranging from 65,000 to 80,000. The antihemorrhagic activity of these factors was stable at a pH range of 1.3-11.5 and at temperatures up to 85 degrees C, for 30 min. The isolated antihemorrhagins also neutralized the proteolytic activity of C. atrox venom, as tested with azocollagen and gelatin, and formed a complex with hemorrhagic toxin e isolated from the same venom. The neutralization capacity of the isolated antihemorrhagins was six times as high as the commercial polyvalent antivenom produced for clinical use.
从锯鳞蝰蛇血清中分离出的几种抗出血因子是糖蛋白，分子量在65,000至80,000之间。这些因子的抗出血活性在pH值1.3 - 11.5范围内以及高达85摄氏度的温度下保持30分钟时稳定。用偶氮胶原蛋白和明胶测试发现，分离出的抗出血素还能中和锯鳞蝰蛇毒液的蛋白水解活性，并与从同一种毒液中分离出的出血毒素e形成复合物。分离出的抗出血素的中和能力是临床使用的商业多价抗蛇毒血清的六倍。
