致密核心分泌颗粒的生物发生。

Dense-core secretory granule biogenesis.

作者信息

Kim Taeyoon, Gondré-Lewis Marjorie C, Arnaoutova Irina, Loh Y Peng

机构信息

Section on Cellular Neurobiology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA.

出版信息

Physiology (Bethesda). 2006 Apr;21:124-33. doi: 10.1152/physiol.00043.2005.

DOI:10.1152/physiol.00043.2005

PMID:16565478

Abstract

The dense-core secretory granule is a key organelle for secretion of hormones and neuropeptides in endocrine cells and neurons, in response to stimulation. Cholesterol and granins are critical for the assembly of these organelles at the trans-Golgi network, and their biogenesis is regulated quantitatively by posttranscriptional and posttranslational mechanisms.

摘要

致密核心分泌颗粒是内分泌细胞和神经元中响应刺激分泌激素和神经肽的关键细胞器。胆固醇和颗粒蛋白对于这些细胞器在反式高尔基体网络中的组装至关重要，并且它们的生物发生通过转录后和翻译后机制进行定量调节。