Heluwaert Frédéric, Santre Charles, Martin Claude, Hilleret Marie-Noëlle, Martin Denis
Service d'Hépato-Gastroentérologie, CH de la région d'Annecy, Annecy.
Gastroenterol Clin Biol. 2006 Feb;30(2):325-6. doi: 10.1016/s0399-8320(06)73176-1.
5FU is one of the most frequently used antioncogenic and cytostatic drug in digestive oncology. It may cause severe adverse events, such as encephalopathy, possibly based on hyperammoniemia, and may lead to coma. We report here the case of a coma with a favorable outcome following 5FU chemotherapy. As any other etiologic findings came to light, hyperammoniemia was discussed as a credible cause.
5-氟尿嘧啶是消化肿瘤学中最常用的抗癌和细胞毒性药物之一。它可能会引发严重的不良事件，比如可能基于高氨血症的脑病，并可能导致昏迷。我们在此报告一例5-氟尿嘧啶化疗后出现昏迷但预后良好的病例。由于未发现其他病因，高氨血症被认为是一个可信的病因。
