Coracin F L, Pizzigatti Correa M E, Camargo E E, Peterson D E, de Oliveira Santos A, Vigorito A C, Borba Oliveira G, de Brito Eid K A, Zulli R, De Souza C A
BMT Unit, Hematology and Blood Transfusion Center (Hemocentro), State University of Campinas, São Paulo, Brazil.
Bone Marrow Transplant. 2006 May;37(10):955-9. doi: 10.1038/sj.bmt.1705351.
Salivary gland dysfunction is a common sequela of hematopoietic progenitor cell transplantation (HPCT). The investigation of major salivary gland dysfunction with sodium pertechnetate scintigraphy is a non-invasive method that provides images of the parotid and submandibular glands. In this prospective trial, 20 HPCT patients were submitted to scintigraphic study with 99mTc-pertechenate and 67Ga in order to evaluate the major salivary glands early involvement following HPCT. Major salivary glands were evaluated prior to HCPT as well as at Days +30, +60 and +100 post transplant. Major salivary glands uptake and clearance of 99mTc-pertechenate results did not demonstrate any functional differences between pre- versus post transplant periods. Results of the 67Ga scan revealed inflammatory infiltration following HPCT, primarily in submandibular glands, suggest a persistent involvement of major salivary glands up to Day +100 after HPCT.
