Heilier Jean-François, Donnez Olivier, Van Kerckhove Valérie, Lison Dominique, Donnez Jacques
Industrial Toxicology and Occupational Medicine Unit, Université catholique de Louvain, Belgium.
Fertil Steril. 2006 May;85(5):1516-8. doi: 10.1016/j.fertnstert.2005.10.041. Epub 2006 Mar 29.
We found, by reverse transcription--real time--polymerase chain reaction, that the expression of aromatase (CYP19) in ovarian, peritoneal endometriosis, and deep endometriotic nodules is significantly different, which strengthens the theory of three distinct clinical entities. Compared with peritoneal endometriosis, ovarian endometriosis exhibits an 8-fold higher expression of aromatase, which suggests that aromatase inhibitors may be particularly active in this form of endometriosis.
我们通过逆转录-实时-聚合酶链反应发现，芳香化酶（CYP19）在卵巢、腹膜子宫内膜异位症和深部子宫内膜异位结节中的表达存在显著差异，这强化了三种不同临床实体的理论。与腹膜子宫内膜异位症相比，卵巢子宫内膜异位症中芳香化酶的表达高8倍，这表明芳香化酶抑制剂可能对这种形式的子宫内膜异位症特别有效。
