噬菌体与生物技术：疫苗、基因治疗和抗菌药物。

Bacteriophages and biotechnology: vaccines, gene therapy and antibacterials.

作者信息

Clark Jason R, March John B

机构信息

Moredun Research Institute, Pentlands Science Park, Bush Loan, Penicuik, Midlothian, EH26 0PZ, UK.

出版信息

Trends Biotechnol. 2006 May;24(5):212-8. doi: 10.1016/j.tibtech.2006.03.003. Epub 2006 Mar 29.

DOI:10.1016/j.tibtech.2006.03.003

PMID:16567009

Abstract

In recent years it has been recognized that bacteriophages have several potential applications in the modern biotechnology industry: they have been proposed as delivery vehicles for protein and DNA vaccines; as gene therapy delivery vehicles; as alternatives to antibiotics; for the detection of pathogenic bacteria; and as tools for screening libraries of proteins, peptides or antibodies. This diversity, and the ease of their manipulation and production, means that they have potential uses in research, therapeutics and manufacturing in both the biotechnology and medical fields. It is hoped that the wide range of scientists, clinicians and biotechnologists currently researching or putting phages to practical use are able to pool their knowledge and expertise and thereby accelerate progress towards further development in this exciting field of biotechnology.

摘要

近年来，人们已经认识到噬菌体在现代生物技术产业中有多种潜在应用：它们被提议作为蛋白质和DNA疫苗的递送载体；作为基因治疗的递送载体；作为抗生素的替代品；用于检测病原菌；以及作为筛选蛋白质、肽或抗体文库的工具。这种多样性，以及它们易于操作和生产的特点，意味着它们在生物技术和医学领域的研究、治疗和制造中都有潜在用途。希望目前正在研究或实际应用噬菌体的广大科学家、临床医生和生物技术专家能够汇聚他们的知识和专业技能，从而加速在这个令人兴奋的生物技术领域取得进一步发展的进程。