Rosai J, Dias P, Parham D M, Shapiro D N, Houghton P
Department of Pathology, Yale University School of Medicine, New Haven, Connecticut.
Am J Surg Pathol. 1991 Oct;15(10):974-81. doi: 10.1097/00000478-199110000-00008.
A typical case of alveolar soft part sarcoma was found to express in a strong and widespread fashion the marker MyoD1 protein. This nuclear phosphoprotein is the product of a regulatory gene that controls the commitment of a cell to myogenic lineage; it therefore provides strong and perhaps definitive evidence in support of the skeletal muscle nature of this enigmatic neoplasm.
一例典型的腺泡状软组织肉瘤被发现以强烈且广泛的方式表达MyoD1蛋白标志物。这种核磷蛋白是一个调控基因的产物，该基因控制细胞向肌源性谱系的定向分化；因此，它为支持这种神秘肿瘤的骨骼肌性质提供了有力且可能确凿的证据。
