[转移因子作为特异性免疫调节剂治疗中重度特应性皮炎]
[Transfer factor as specific immunomodulator in the treatment of moderate-severe atopic dermatitis].
作者信息
Flores Sandoval G, Gómez Vera J, Orea Solano M, López Tiro J, Serrano E, Rodríguez Abraham, Rodríguez Azucena, Estrada Parra S, Jiménez Saab N
机构信息
Servicio de inmunología y alergia, Hospital Licenciado Adolfo López Mateos, ISSSTE, Florida, México, DF.
出版信息
Rev Alerg Mex. 2005 Nov-Dec;52(6):215-20.
BACKGROUND
Atopic dermatitis is a skin inflammatory disease which has been associated to high levels of IgE, eosinophiles and change of T lymphocytes. The transfer factor is an immunomodulator active substance and decreases the number of inflammatory cells and the severity of the symptoms of atopic dermatitis.
OBJECTIVE
To determine the efficacy of the transfer factor as treatment of moderate and severe atopic dermatitis.
MATERIAL AND METHODS
Articles related to treatment with transfer factor in the atopic dermatitis were looked up in Medline and EMBASE, and the ones referring to controlled studies in patients with moderate and severe atopic dermatitis in accord to SCORAD.
RESULTS
We found seven articles with 121 patients and 88 controls demonstrating significant decrease in the symptoms of the SCORAD index, decreased IgE, and eosinophils in patients treated with transfer factor.
CONCLUSIONS
The transfer factor is a choice treatment for moderate and severe atopic dermatitis.
背景
特应性皮炎是一种皮肤炎症性疾病，与高水平的免疫球蛋白E、嗜酸性粒细胞及T淋巴细胞变化有关。转移因子是一种免疫调节活性物质，可减少炎症细胞数量并减轻特应性皮炎症状的严重程度。
目的
确定转移因子治疗中重度特应性皮炎的疗效。
材料与方法
在医学在线数据库（Medline）和荷兰医学文摘数据库（EMBASE）中检索与转移因子治疗特应性皮炎相关的文章，以及符合特应性皮炎严重程度评分（SCORAD）标准的中重度特应性皮炎患者对照研究的文章。
结果
我们发现7篇文章，涉及121例患者和88例对照，结果显示接受转移因子治疗的患者的SCORAD指数症状显著减轻，免疫球蛋白E和嗜酸性粒细胞减少。
结论
转移因子是治疗中重度特应性皮炎的一种选择。
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