Beigelman R L, Descalzo A M, Storino R A, Milei J
Hospital Juan A. Fernández y Cardiopsis, Buenos Aires, Argentina.
Arch Inst Cardiol Mex. 1991 May-Jun;61(3):231-5.
The aim of this paper is to report for the first time the association between bronchiolo-alveolar carcinoma and acute myocardial infarction (AMI). Two patients suffering from this association were studied. A 59 year old male, diabetic, alcoholic and smoker was admitted because a diaphragmatic AMI. An interventricular septal defect and papillary posterior muscle rupture were confirmed at autopsy. A 0.8 cm diameter friable mass was found in the right lung superior lobe. The second case was a 69 year old male, smoker, who presented with a diaphragmatic and right ventricular posterior wall AMI. A round 1 cm diameter tumor was observed at the right lung superior lobe. It had a caseous aspect lying over a fibrous scar. Both cases had severe right coronary artery narrowings with recent occlusive thrombi. The cardiac valves were free of non-bacterial thrombotic endocarditis. Therefore the possibility of coronary embolization was discarded. As lung carcinomas produce vasospastic and thrombogenic mucins, these substances could have been responsible for the acute coronary thrombosis.
本文旨在首次报告细支气管肺泡癌与急性心肌梗死（AMI）之间的关联。对两名患有这种关联疾病的患者进行了研究。一名59岁男性，患有糖尿病、酗酒且吸烟，因膈面AMI入院。尸检证实存在室间隔缺损和后乳头肌破裂。在右肺上叶发现一个直径0.8厘米的易碎肿块。第二例是一名69岁男性，吸烟，表现为膈面和右心室后壁AMI。在右肺上叶观察到一个直径1厘米的圆形肿瘤。它呈干酪样外观，位于纤维瘢痕之上。两例患者均有严重的右冠状动脉狭窄及近期闭塞性血栓形成。心脏瓣膜无非细菌性血栓性心内膜炎。因此排除了冠状动脉栓塞的可能性。由于肺癌会产生血管痉挛性和血栓形成性粘蛋白，这些物质可能是急性冠状动脉血栓形成的原因。
