Proapoptotic effect of Uncaria tomentosa extracts.

作者信息

De Martino Laura, Martinot José Luis Silva, Franceschelli Silvia, Leone Arturo, Pizza Cosimo, De Feo Vincenzo

机构信息

Dipartimento di Scienze Farmaceutiche, Università degli Studi di Salerno Via Ponte don Melillo, Fisciano (Salerno), Italy.

出版信息

J Ethnopharmacol. 2006 Aug 11;107(1):91-4. doi: 10.1016/j.jep.2006.02.013. Epub 2006 Mar 29.

Uncaria tomentosa ("Uña de gato") (Rubiaceae) is widely used in South America for treatment of gastritis, arthritis, cancer and inflammatory conditions. Recent literature reports cytostatic, antiproliferative, anti-inflammatory, mutagenic and anti-mutagenic properties of extracts of the plant. The present study investigates the possible proapoptotic mechanism via the activation of caspase3, in cytostatic effects of root bark extracts of Uncaria tomentosa on three different tumoral cell lines.