Khan Gulfaraz
Kingston University, Kingston upon Thames, Surrey, UK.
Exp Hematol. 2006 Apr;34(4):399-406. doi: 10.1016/j.exphem.2005.11.008.
The association between chronic inflammation and cancer has been known for well over a century. However, direct evidence detailing the role of inflammation in carcinogenesis has been slow in forthcoming. A number of recent studies suggest that the gaps in our understanding of the molecular pathways bridging the link between inflammation and cancer are slowly beginning to close and that this relationship is more deep-rooted than had been previously believed. This review addresses the link between inflammation and Hodgkin's lymphoma (HL), a malignancy which has many features reminiscent of chronic inflammation. The role of Epstein-Barr virus (EBV) in the pathogenesis of HL is discussed, along with an outline of our current understanding of the cellular nature and development of Reed-Sternberg cells, the malignant cells of HL. The involvement of cytokines and chemokines as orchestrators of inflammation and vehicles for chemical cross-talk between the malignant cells and the reactive inflammatory infiltrate forms a major part of the review. It is suggested that chronic inflammation, triggered by factors such as EBV, is likely to contribute to tumor cell proliferation, progression, and inhibition of apoptosis. Furthermore, it is proposed that the pro-inflammatory transcription factor NF-kappaB plays a central role in many of these processes.
慢性炎症与癌症之间的关联已为人所知达一个多世纪之久。然而，详细阐述炎症在致癌过程中作用的直接证据姗姗来迟。近期的一些研究表明，我们在理解连接炎症与癌症之间分子途径方面的差距正逐渐缩小，而且这种关系比之前认为的更为根深蒂固。本综述探讨了炎症与霍奇金淋巴瘤（HL）之间的联系，HL是一种具有许多类似慢性炎症特征的恶性肿瘤。文中讨论了爱泼斯坦 - 巴尔病毒（EBV）在HL发病机制中的作用，同时概述了我们目前对HL恶性细胞里德 - 斯腾伯格细胞的细胞性质及发育的理解。细胞因子和趋化因子作为炎症的协调者以及恶性细胞与反应性炎症浸润之间化学信号传导的载体，其参与情况构成了本综述的主要部分。研究表明，由EBV等因素引发的慢性炎症可能有助于肿瘤细胞增殖、进展以及抑制细胞凋亡。此外，有人提出促炎转录因子核因子 - κB在许多此类过程中起着核心作用。
