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EBV 对儿科患者外周巨噬细胞极化细胞因子的影响。

EBV Impact in Peripheral Macrophages' Polarization Cytokines in Pediatric Patients.

机构信息

Multidisciplinary Institute for Investigation in Pediatric Pathologies (IMIPP), CONICET-GCBA, Molecular Biology Laboratory, Pathology Division, Ricardo Gutiérrez Children's Hospital, Buenos Aires 1425, Argentina.

出版信息

Viruses. 2023 Oct 17;15(10):2105. doi: 10.3390/v15102105.

DOI:10.3390/v15102105
PMID:37896882
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10612087/
Abstract

Macrophages are exceptionally flexible cells. The presence of inflammatory cytokines such as IFN-γ and TNF-α results in an M1 (CD68) activation, while cytokines such as IL-10 or TGF-β induce the M2 (CD163) activation. Our aim was to study the behavior of peripheral cytokines involved in macrophage polarization and relate them with tissue findings to further comprehend the role of macrophages in EBV pediatric infection. We studied cytokine expression in tonsils and peripheral blood samples of children in different stages of infection. Peripheral cytokines were compared with macrophage polarization markers and viral protein expression in tonsils. Only IL-10 showed a negative correlation between compartments, exclusively in patients undergoing viral reactivation (R). Higher expressions of peripheral IL-1β, IL-23, and IL-12p40 in R children were observed. Lower expressions of local and peripheral TNF-α in patients with broader expressions of latent and lytic viral proteins were demonstrated. In healthy carrier (HC) patients, IL-23 positively correlated with CD163, and IP-10 positively correlated with CD68. Our results indicated that EBV might modulate antigen expression in the presence of TNF-α and influence peripheral cytokine expression differently in each stage of infection. Moreover, peripheral cytokines might have a particular role in macrophage polarization in HC.

摘要

巨噬细胞是一种具有高度灵活性的细胞。炎症细胞因子（如 IFN-γ 和 TNF-α）的存在会导致 M1（CD68）激活，而 IL-10 或 TGF-β 等细胞因子则会诱导 M2（CD163）激活。我们的目的是研究参与巨噬细胞极化的外周细胞因子的行为，并将其与组织学发现相关联，以进一步了解巨噬细胞在 EBV 儿童感染中的作用。我们研究了不同感染阶段儿童扁桃体和外周血样本中的细胞因子表达。将外周细胞因子与巨噬细胞极化标志物和扁桃体中的病毒蛋白表达进行了比较。只有 IL-10 在两个部位之间呈负相关，仅在发生病毒再激活（R）的患者中如此。在 R 儿童中观察到外周 IL-1β、IL-23 和 IL-12p40 的表达更高。在潜伏和裂解病毒蛋白表达更广泛的患者中，局部和外周 TNF-α 的表达较低。在健康携带者（HC）患者中，IL-23 与 CD163 呈正相关，IP-10 与 CD68 呈正相关。我们的结果表明，EBV 可能在 TNF-α 的存在下调抗原表达，并在感染的每个阶段以不同的方式影响外周细胞因子的表达。此外，外周细胞因子在 HC 中的巨噬细胞极化中可能具有特殊作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ba4/10612087/5eefc09fedee/viruses-15-02105-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ba4/10612087/cab0dd4f9b6f/viruses-15-02105-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ba4/10612087/d431baec54de/viruses-15-02105-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ba4/10612087/b9eae636a30b/viruses-15-02105-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ba4/10612087/1aa1df38a804/viruses-15-02105-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ba4/10612087/5eefc09fedee/viruses-15-02105-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ba4/10612087/cab0dd4f9b6f/viruses-15-02105-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ba4/10612087/d431baec54de/viruses-15-02105-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ba4/10612087/b9eae636a30b/viruses-15-02105-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ba4/10612087/1aa1df38a804/viruses-15-02105-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ba4/10612087/5eefc09fedee/viruses-15-02105-g005.jpg

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