在豚鼠侵袭性曲霉病模型中，伏立康唑和两性霉素B脂质体的序贯或联合抗真菌治疗。
Sequential or combination antifungal therapy with voriconazole and liposomal amphotericin B in a Guinea pig model of invasive aspergillosis.
作者信息
Kirkpatrick William R, Coco Brent J, Patterson Thomas F
机构信息
The University of Texas Health Science Center at San Antonio, Department of Medicine, Division of Infectious Diseases, 7703 Floyd Curl Drive, Mail Code 7881, San Antonio, TX 78229-3900, USA.
出版信息
Antimicrob Agents Chemother. 2006 Apr;50(4):1567-9. doi: 10.1128/AAC.50.4.1567-1569.2006.
Abstract
We evaluated combinations of voriconazole (VRC) and liposomal amphotericin B (L-AMB) in a guinea pig invasive aspergillosis model. Simultaneous VRC and L-AMB was most effective, although VRC monotherapy was also effective. These regimens as well as sequential L-AMB followed by VRC were more effective than L-AMB alone or VRC followed by L-AMB.
摘要
我们在豚鼠侵袭性曲霉病模型中评估了伏立康唑（VRC）和两性霉素B脂质体（L-AMB）的联合用药情况。同时使用VRC和L-AMB最为有效，不过VRC单药治疗也有效。这些治疗方案以及先使用L-AMB后使用VRC的序贯疗法比单独使用L-AMB或先使用VRC后使用L-AMB更有效。
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2
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3
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5
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9
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