Maupomé Gerardo, Peters Dawn, Rush William A, Rindal D Brad, White B Alex
Oral Health Research Institute, Department of Preventive and Community Dentistry, Indiana University/Purdue University at Indianapolis School of Dentistry, 415 Lansing Street, Indianapolis, IN 46202-2876, USA.
J Public Health Dent. 2006 Winter;66(1):49-56. doi: 10.1111/j.1752-7325.2006.tb02551.x.
This retrospective, longitudinal cohort study quantified the strength of the association between xerogenic cardiovascular medication use and dental restorations, using the latter as a proxy measure for dental caries experience.
Study data were collected from 11 years of electronic clinical/pharmacy records in two large dental group practices associated with managed care organizations (MCO). Records were extracted for all members who were at least 55 years old at the end of the 11 year window, and had at least 48 months of concurrent dental, medical, and pharmacy coverage. The authors identified 4448 individuals whose only xerogenic medication exposure was to drugs treating a cardiovascular condition. This group was compared to a group not taking any medications (n=1183), and a group taking medications with no known xerostomic side effect (n=5622). Poisson regression compared restoration incidence and mean restoration rates among the three groups.
MCO members taking cardiovascular or nonxerogenic medications had higher restoration incidence and mean restoration rates than individuals taking no medications. A small difference in mean restoration rate between the non-xerogenic medication group and the cardiovascular drug group was observed; no significant difference in restoration incidence was seen between these two groups.
This study provides objective quantification of cardiovascular medication's long-term effects on increased restorations in older adults. When grouped under a single category labeled "cardiovascular", drugs with effects targeting the cardiovascular system did not appear to unequivocally lead to higher restorative experiences.
这项回顾性纵向队列研究，以牙齿修复作为龋齿经历的替代指标，量化了致干性心血管药物使用与牙齿修复之间关联的强度。
研究数据收集自与管理式医疗组织（MCO）相关的两家大型牙科集团诊所11年的电子临床/药房记录。提取了在11年观察期结束时至少55岁，且同时拥有至少48个月牙科、医疗和药房保险覆盖的所有成员的记录。作者确定了4448名仅接触治疗心血管疾病药物的个体。将该组与未服用任何药物的组（n = 1183）以及服用无已知口干副作用药物的组（n = 5622）进行比较。采用泊松回归比较三组之间的修复发生率和平均修复率。
服用心血管药物或非致干性药物的MCO成员比未服用药物的个体有更高的修复发生率和平均修复率。观察到非致干性药物组和心血管药物组之间的平均修复率有微小差异；这两组之间的修复发生率没有显著差异。
本研究客观量化了心血管药物对老年人修复增加的长期影响。当归类于单一的“心血管”类别时，作用于心血管系统的药物似乎并未明确导致更高的修复经历。
