Thomson W M, Slade G D, Spencer A J
Department of Dentistry, University of Adelaide, Australia.
Gerodontology. 1995 Dec;12(12):104-10. doi: 10.1111/j.1741-2358.1995.tb00139.x.
Medication has long been implicated as a potential risk factor for dental caries among elderly people, although epidemiological studies have reported inconsistent associations between medication usage and dental caries experience. This paper aimed to describe the frequency of medication usage, and to examine associations between medication usage and dental caries experience among non-institutionalized persons aged 60+ years in South Australia. A cross-sectional survey design was used to collect interview data about prescription medication usage from 1,650 people. Oral examinations were conducted among 848 people to obtain information about coronal and root canes experience. The number of prescribed medications taken ranged from 0 to 17, and the mean number taken was 1.8 (sd, 1.9). This was higher in older subjects and females. Four medication categories accounted for almost three-quarters of the medications taken; of those, cardiovascular drugs (including diuretics) accounted for three, with analgesics the only non-cardiovascular class. Subjects taking 3 or more prescription medications had a higher Root Caries Index (RCI, mean = 14.43; P < 0.01) than those taking one or two (mean = 11.50), and those who were taking none (mean = 12.02). Examination of particular medication types revealed that people who took antidepressants and antiulcer drugs had significantly higher RCI values (P < 0.05). There was only a moderate association between medication usage and root caries experience which may be attributable to xerogenic effects of medication, or non-causal associations with underlying medical conditions.
长期以来,药物一直被认为是老年人患龋齿的潜在风险因素,尽管流行病学研究报告了药物使用与龋齿经历之间的关联并不一致。本文旨在描述药物使用的频率,并研究南澳大利亚州60岁及以上非机构化人群的药物使用与龋齿经历之间的关联。采用横断面调查设计,收集了1650人的处方药使用访谈数据。对848人进行了口腔检查,以获取有关冠龋和根龋经历的信息。服用的处方药数量从0到17不等,平均服用数量为1.8(标准差为1.9)。在老年受试者和女性中这一数值更高。四类药物几乎占所服用药物的四分之三;其中,心血管药物(包括利尿剂)占了三类,镇痛药是唯一的非心血管类药物。服用3种或更多处方药的受试者的根龋指数(RCI,平均值 = 14.43;P < 0.01)高于服用1种或2种处方药的受试者(平均值 = 11.50)以及未服用任何处方药的受试者(平均值 = 12.02)。对特定药物类型的检查显示,服用抗抑郁药和抗溃疡药的人RCI值显著更高(P < 0.05)。药物使用与根龋经历之间只有适度的关联,这可能归因于药物的致干燥作用,或与潜在疾病的非因果关联。