Milman N, Sengeløv H, Dombernowsky P
Department of Pulmonary Medicine, Gentofte Hospital, Hellerup, Denmark.
Br J Cancer. 1991 Nov;64(5):895-8. doi: 10.1038/bjc.1991.421.
A longitudinal study of iron status markers (haemoglobin (Hb), serum (S-) iron, S-transferrin, transferrin saturation, S-ferritin) was performed in 31 chemotherapy treated patients with small cell lung cancer. At discovery, eight patients were anaemic (Hb less than 121 g l-1). Hb, S-iron and transferrin saturation were lower (P less than 0.01), and S-ferritin higher (P less than 0.01) than in healthy subjects. Chemotherapy induced an immediate fall in Hb (P less than 0.003), increase in S-iron (P less than 0.003) and transferrin saturation (P less than 0.001). Later in the disease a fall in S-transferrin (P less than 0.006) and an increase in S-ferritin (P less than 0.02) occurred. Thirty patients died during the 2 years observation. S-ferritin at discovery was correlated to performance status score (r = 0.57, P = 0.01) and to survival (r = -0.63, P less than 0.0002). Patients with S-ferritin less than or equal to 400 micrograms l-1 (n = 13) had longer survival than those with S-ferritin greater than 400 micrograms l-1 (n = 18) (P = 0.004).
对31例接受化疗的小细胞肺癌患者进行了铁状态标志物（血红蛋白（Hb）、血清铁（S-铁）、转铁蛋白、转铁蛋白饱和度、血清铁蛋白）的纵向研究。在确诊时，8例患者贫血（Hb低于121 g/l）。与健康受试者相比，患者的Hb、S-铁和转铁蛋白饱和度较低（P<0.01），而血清铁蛋白较高（P<0.01）。化疗导致Hb立即下降（P<0.003），S-铁（P<0.003）和转铁蛋白饱和度增加（P<0.001）。在疾病后期，S-转铁蛋白下降（P<0.006），血清铁蛋白增加（P<0.02）。在2年的观察期内，30例患者死亡。确诊时的血清铁蛋白与体能状态评分相关（r = 0.57，P = 0.01），与生存率相关（r = -0.63，P<0.0002）。血清铁蛋白≤400μg/l的患者（n = 13）比血清铁蛋白>400μg/l的患者（n = 18）生存期更长（P = 0.004）。
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