Runyoro Deborah K B, Matee Mecky I N, Ngassapa Olipa D, Joseph Cosam C, Mbwambo Zakaria H
Department of Pharmacognosy, School of Pharmacy, Muhimbili University College of Health Sciences P,O Box 65013, Dar Es Salaam, Tanzania.
BMC Complement Altern Med. 2006 Mar 30;6:11. doi: 10.1186/1472-6882-6-11.
Candida albicans has become resistant to the already limited, toxic and expensive anti-Candida agents available in the market. These factors necessitate the search for new anti-fungal agents.
Sixty-three plant extracts, from 56 Tanzanian plant species obtained through the literature and interviews with traditional healers, were evaluated for anti-Candida activity. Aqueous methanolic extracts were screened for anti-Candida activity by bioautography agar overlay method, using a standard strain of Candida albicans (ATCC 90028).
Twenty- seven (48%) out of the 56 plants were found to be active. Extracts of the root barks of Albizia anthelmintica and Balanites aegyptiaca, and roots of Plectranthus barbatus showed strong activity.
The extracts that showed strong anti-Candida activity are worth of further investigation in order to isolate and identify the active compounds.
白色念珠菌已对市场上现有的数量有限、有毒且昂贵的抗念珠菌药物产生耐药性。这些因素使得寻找新的抗真菌药物成为必要。
通过文献检索和与传统治疗师访谈获得了来自56种坦桑尼亚植物的63种植物提取物，对其抗念珠菌活性进行了评估。采用水甲醇提取物，通过生物自显影琼脂覆盖法，使用白色念珠菌标准菌株（ATCC 90028）筛选抗念珠菌活性。
56种植物中有27种（48%）被发现具有活性。驱虫合欢和埃及 balanites 的根皮提取物以及毛花延命草的根表现出较强的活性。
表现出较强抗念珠菌活性的提取物值得进一步研究，以分离和鉴定活性化合物。
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