小鼠巨细胞病毒对抗抗原呈递的干扰导致CD8 T细胞无法在唾液腺中控制病毒。
Murine cytomegalovirus interference with antigen presentation contributes to the inability of CD8 T cells to control virus in the salivary gland.
作者信息
Lu Xiuju, Pinto Amelia K, Kelly Ann M, Cho Kathy S, Hill Ann B
机构信息
Department of Molecular Microbiology and Immunology, L220, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, USA.
出版信息
J Virol. 2006 Apr;80(8):4200-2. doi: 10.1128/JVI.80.8.4200-4202.2006.
Abstract
Compared to other organs, murine cytomegalovirus (MCMV) replication in the salivary gland is uniquely resistant to CD8 T-cell control. The contribution of viral genes that interfere with antigen presentation (VIPRs) to this resistance was assessed using a mutant lacking MCMV's known VIPRs. Salivary gland titers of the VIPR-deficient virus were at least 10-fold lower than those of the wild type during the persistent phase of infection; the defect was reversed by depleting CD8 T cells. Thus, VIPRs contribute to CD8 T cells' inability to control virus in the salivary gland.
摘要
与其他器官相比，小鼠巨细胞病毒（MCMV）在唾液腺中的复制对CD8 T细胞的控制具有独特的抗性。使用缺乏MCMV已知干扰抗原呈递病毒基因（VIPRs）的突变体，评估了这些病毒基因对这种抗性的作用。在感染持续阶段，缺乏VIPR的病毒在唾液腺中的滴度比野生型至少低10倍；通过耗尽CD8 T细胞可逆转该缺陷。因此，VIPRs导致CD8 T细胞无法控制唾液腺中的病毒。
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