Carpentier P H
Laboratorie d'Hémodynamique Périphérique et de Microcirculation, Centre Hospitalier Universitaire de Grenoble, La Tronche, France.
Blood Vessels. 1991;28 Suppl 1:33-7. doi: 10.1159/000158918.
Vasomotion is a potential target for drugs in vascular diseases. In this work, the effects on arteriolar vasomotion of norepinephrine, phentolamine and the vasoactive drug buflomedil were assessed in the hamster skinfold preparation. Results show the strong vasokinetic properties of alpha-sympathetic receptor activation by norepinephrine and an expected depressive effect of the alpha-blocker phentolamine. Buflomedil 10(-4) M enhances vasomotion and arteriolar reactivity and does not interfere with norepinephrine. The mechanism of these properties of buflomedil remains to be investigated.
血管运动是血管疾病药物治疗的一个潜在靶点。在本研究中，我们在仓鼠皮肤褶制备模型中评估了去甲肾上腺素、酚妥拉明和血管活性药物丁咯地尔对小动脉血管运动的影响。结果显示，去甲肾上腺素激活α-交感神经受体具有很强的血管动力学特性，而α-阻滞剂酚妥拉明具有预期的抑制作用。10(-4)M的丁咯地尔可增强血管运动和小动脉反应性，且不干扰去甲肾上腺素的作用。丁咯地尔这些特性的机制仍有待研究。
