Goldbeter A
Service de Chimie physique, faculté des Sciences de l'Université libre de Bruxelles.
Bull Mem Acad R Med Belg. 1991;146(1-2):113-21; discussion 122-7.
An important function of biological rhythms is to support the frequency encoding of intercellular communications. Two examples of this phenomenon are discussed, namely, communication by cyclic AMP pulses in the slime mold Dictyostelium, and the pulsatile secretion of gonadotropic hormones. The existence of an optimal frequency of stimulation in these two systems possesses clinical implications, as attested by the use of pulsatile hormonal therapies in endocrinology. More generally, the pulsatile administration of some drugs, at the appropriate frequency, could maximize their physiological effect. Such a generalized chronopharmacology would take into account the kinetic characteristics of desensitization and resensitization in target cells, and would not be limited to the sole consideration of circadian rhythms within the organism.
生物节律的一个重要功能是支持细胞间通讯的频率编码。本文讨论了这一现象的两个例子，即黏菌盘基网柄菌中通过环磷酸腺苷脉冲进行的通讯，以及促性腺激素的脉冲式分泌。这两个系统中存在最佳刺激频率具有临床意义，内分泌学中脉冲式激素疗法的应用就证明了这一点。更普遍地说，以适当频率脉冲给药某些药物，可以使其生理效应最大化。这种广义的时辰药理学将考虑靶细胞中脱敏和再敏化的动力学特征，而不仅限于考虑生物体中的昼夜节律。
