Goldbeter A, Li Y, Dupont G
Faculté des Sciences, Université Libre de Bruxelles, Belgium.
Biomed Biochim Acta. 1990;49(8-9):935-40.
The role of biological rhythms in the control of intercellular communication is briefly reviewed. In particular, pulsatile cAMP signaling in the slime mold, Dictyostelium discoideum, the pulsatile release of the hormone GnRH in higher animals, and cytosolic calcium oscillations are discussed, with special reference to underlying molecular mechanisms. It is pointed out that there exists an optimal pattern of periodic stimulation by hormones and that frequency encoding has some advantages in comparison with amplitude encoding, especially concerning the accuracy of control.
本文简要综述了生物节律在细胞间通讯控制中的作用。特别讨论了黏菌盘基网柄菌中的脉冲式cAMP信号传导、高等动物中促性腺激素释放激素（GnRH）的脉冲式释放以及胞质钙振荡，并特别提及了潜在的分子机制。文中指出，激素存在一种最佳的周期性刺激模式，并且与幅度编码相比，频率编码具有一些优势，特别是在控制精度方面。
